• Pediatric Cancer Risk Program

    The Pediatric Cancer Risk Program (PCRP) at Dana-Farber/Boston Children's Cancer and Blood Disorders Center provides multidisciplinary, consultative care to patients and their families whose condition or family history suggests an increased risk of cancer.

    The Pediatric Cancer Risk Program (PCRP) offers patients access to expert pediatric geneticists, genetic counselors and other specialists at Boston Children's Hospital, as well as world-renowned pediatric oncologists from Dana-Farber/Boston Children's.

    The first of its kind in New England, our program accepts referrals, second opinions and consultations for evaluation of:

    • children who have cancers with known hereditary links
    • children whose genetic defects are associated with cancer development
    • children with family histories that place them at a higher risk for cancer development

    Who we help

    Referral to the PCRP is recommended for children who have:

    • a history of cancer with known hereditary links
    • a strong family history of cancer
    • multiple family members with colon cancer
    • parents with known cancer predisposition syndromes

    Referrals are also recommended for children with the following genetic syndromes or histories:

    • ataxia telangiectasia
    • Beckwith-Wiedemann syndrome
    • Cowden syndrome
    • familial adenomatous polyposis
    • Li-Fraumeni syndrome
    • multiple endocrine neoplasia
    • pheochromocytoma 
    • retinoblastoma 
    • Von Hippel-Lindau syndrome
    • X-linked lymphoproliferative syndrome

    Our Treatment Approach

    Our integrated approach to care offers comprehensive evaluation and follow-up for children at risk for cancer. If needed, we will also recommend referrals to additional specialists.

    All cases are reviewed in a multidisciplinary clinic conference.

    In addition, adult family members of at-risk children may be referred to Dana-Farber Cancer Institute's Cancer Genetics and Prevention Program.

    A cancer risk assessment can provide additional information about cancer risk and appropriate screening. A certified genetic counselor assesses each case according to individual needs, coordinates all patient visits and determines if the patient should be seen by an oncologist at Dana-Farber/Boston Children's or a geneticist at Boston Children's Hospital.

    The Care Team

    Our team includes members from the Division of Genetics at Boston Children's Hospital and the Cancer Genetics and Prevention Program at Dana-Farber Cancer Institute.

    • Lisa Diller, MD, Chief Medical Director, Dana-Farber/Boston Children's
    • Mira Irons, MD, Associate Chief, Division of Genetics, Boston Children's Hospital
    • Stephen Huang, MD, Director, Thyroid Program, Boston Children's Hospital
    • Victor Fox, MD, Director, Center for Pediatric Polyposis, Boston Children's Hospital
    • Junne Kamihara, MD, PhD 
    • Jill Brace O'Neill, MS, RN-CS, PNP, Pediatric Nurse Practitioner
    • Wen-Hann Tan, BMBS, Geneticist
    • Katherine Schneider, MPH, CGC, Genetic Counselor
    • Carly Grant, MS, CGCMO, Genetic Counselor
    • Sharyn Lincoln, MS, CGC, Genetic Counselor

    Contact Us

    The Pediatric Cancer Risk Program is located at:

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    3rd Floor, Dana Building
    Boston, MA 02215
    Phone: 1-617-355-4388
    Fax: 1-617-730-0466
    Email: CancerRisk@childrens.harvard.edu 

    International Patients

    For families residing outside of the United States, please contact Children's International Center, which facilitates the medical review of patient records and appointment scheduling and which provides assistance with customs and immigration, transportation, hotel and housing accommodations.

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