• Hemophagocytic Lymphohistiocytosis Overview

    Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal condition in which certain white blood cells (histiocytes and lymphocytes) build up in and damage organs, including the bone marrow, liver and spleen, and destroy other blood cells. It most commonly affects infants and young children. In addition, certain aspects of immune function, such as natural killer cell and cytotoxic T-cell activity, are abnormal in HLH. While HLH is not cancer, certain cancer treatments, including chemotherapy, can be used to treat it.

    HLH may be inherited (familial) or caused by another condition (secondary), such as infection. Familial HLH usually affects children under 1 year of age, while the secondary form typically occurs after age 6. A genetic cause is identified in most, but not all, cases of familial HLH.

    Hemophagocytic Lymphohistiocytosis Treatment at Dana-Farber/Boston Children’s

    Children with HLH are treated at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center through our Histiocytosis Program. Continue reading to learn more about hemophagocytic lymphohistiocytosis or visit the Histiocytosis Program homepage to learn about our expertise and treatment options.

    Symptoms & Diagnosis

    The symptoms of HLH include:

    • Fever
    • Cytopenias—low count of one or more of the types of blood cells:
      • Neutropenia: low count of white blood cells that fight infection
      • Anemia: low count of red blood cells that carry oxygen
      • Thrombocytopenia: low count of platelets that prevent bleeding
    • Enlarged liver and/or spleen
    • Abdominal distension, abdominal pain
    • Weight loss, failure to thrive
    • Rash
    • Jaundice
    • Enlarged lymph nodes
    • Malaise

    Children with HLH may also have central nervous system symptoms, including headache, irritability, sleepiness, or seizures.

    Doctors usually diagnose HLH with:

    • Blood tests
    • Bone marrow biopsy
    • Spinal tap (also called lumbar puncture)

    Treatment & Care

    HLH may be fatal if untreated. Rapid diagnosis and early therapy are key. The most common treatments include:

    • Steroid medication, such as dexamethasone
    • Chemotherapy, such as etoposide 
    • Chemotherapy administered directly into the spinal fluid (also called intrathecal therapy)
    • Immunosuppressive medications, such as cyclosporine
    • Immunoglobulin, a substance made from human blood plasma that contains antibodies
    • Antibiotics or antiviral medications to prevent or treat infections
    • Stem cell transplant 

    Long-term Outlook

    Familial HLH is fatal without treatment, with median survival of about two to six months. Chemotherapy and/or immunotherapy temporarily control the disease, but symptoms inevitably return. Stem cell transplant is the only way to cure familial HLH. The five-year survival rate for children who have undergone a stem cell transplant is 66 percent. Infections, especially fungal infections, are an important cause of death in children with HLH.

    Secondary HLH can be effectively treated with chemotherapy and/or immunotherapy medications. Stem cell transplant is not necessary in most cases of secondary HLH. However, children without a known genetic cause for the HLH who experience progressive or recurrent disease are candidates for stem cell transplant.