• Adamantinoma

    Adamantinomas are slow-growing cancerous bone tumors that form primarily in the tibia (shin bone) but occasionally in the jaw, forearm, hands, or feet. About 20 percent of the time, these tumor spread to the lungs or nearby lymph nodes.

    These rare tumors, which most often affect teenage boys and young men, usually occur after bones stop growing and require aggressive treatment. While there is no known cause, patients with adamantinoma have usually sustained trauma to the affected area.

    Adamantinoma at Dana-Farber/Boston Children’s

    Children and young adults with adamantinoma are treated at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center through our Bone and Soft Tissue Tumors Program. Continue reading to learn more about adamantinoma or visit the Bone and Soft Tissue Tumors Program page to learn about our expertise and treatment options for this condition.

    Symptoms and Diagnosis

    The symptoms of adamantinoma may appear over a short period of time or may occur for six months or more. The most common are:

    • Pain (sharp or dull) at the tumor site
    • Swelling and/or redness at the tumor site
    • Increased pain with activity or lifting
    • Limping
    • Decreased movement of the affected limb

    In most cases, an injury brings a child to the doctor, where an X-ray may show a bone abnormality. In addition to a physical examination, other diagnostic procedures include:

    • Diagnostic imaging
    • Biopsy
    • Bone scan to determine the cause of pain and inflammation
    • Blood and urine tests

    After all tests are completed, doctors will be able to outline the best treatment options.

    Treatment and Care Options

    The best treatment option for adamantinoma is surgery because these tumors don’t generally respond to chemotherapy or radiation therapy. Surgery may include:

    • Limb-salvage surgery to help preserve the limb by removing the tumor and some healthy tissue surrounding it
    • Amputation if the tumor involves major nerves or blood vessels

    Progressive or Recurrent Disease

    Recurrent adamantinoma is generally treated through additional surgery.

    Long-Term Outlook

    When treated with surgery, the majority of children with adamantinoma have a very positive long-term outlook. The 10-year survival rate is around 85 percent.
  • Contact Us

    Our specialized new patient coordinators can answer your questions about treatment options and becoming a patient.
  • Solid Tumor Clinical Trials

    Through research and clinical trials, we are developing innovative therapies and helping to improve treatment for solid tumors.callout bg
  • Treating Solid Tumors

    Lindsay Frazier, MD, explains how a multidisciplinary team of specialists come together to deliver care for solid tumors.