Leslie E. Lehmann, MD

Clinical Director, Pediatric Stem Cell Transplant Center

Institute Physician

Assistant Professor of Pediatrics, Harvard Medical School
Office Phone: 617-632-4882
Appointment Phone: 617-632-3961
Fax: 617-632-2095
Preferred Contact Method: Office phone

General

Treatment Centers
Discipline
Pediatric Hematology/Oncology
Clinical Interests
Global health, Hematopoietic stem cell transplantation, Late effects of transplantation, Role of exercise in stem cell transplantation, Second transplants, Stem cell transplantation for sickle cell disease and thalassemia, Transplants for bone marrow failure syndromes

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA  02215

Background

Board Certifications
Pediatric Hematology/Oncology
Pediatrics, 1992
Fellowships
Boston Children's Hospital/Dana-Farber Cancer Institute, Pediatric Hematology/Oncology
Residency
Duke University, Pediatrics
Medical School
Duke University
Biography
Dr. Lehmann attended Harvard College and received her MD from Duke University Medical School, where, after finishing a pediatric residency, she spent a year as chief resident. She completed a pediatric hematology-oncology fellowship at DFCI/Children's Hospital Boston in 1996 and subsequently joined the faculty. In 1998, she became medical director of the Pediatric Transplant Unit at Children's Hospital and, in 2007, was appointed clinical director of the Pediatric Stem Cell Transplant Program.
Research

Hematopoietic Stem Cell Transplants and Related Toxicity

Hematopoietic stem cell transplantation (HSCT) is a medically complex modality that can offer a chance of cure to children with both malignant and nonmalignant conditions. Although remarkable progress has been made in the field over the past few decades, the associated risks of acute mortality and chronic complications limit the applicability of HSCT. Our research focuses on both prevention and amelioration of these toxicities.

With respect to decreasing the acute complications of transplant, we have examined the role of defibrotide, an agent that is effective in treating patients with severe veno-occlusive disease of the liver, and explored how to best address the nutritional needs of our patients. We have also worked to characterize the chronic pulmonary conditions associated with allogeneic transplant in the pediatric setting and, in conjunction with our colleagues in dental medicine, described the oral manifestations of graft-versus-host disease (GVHD). We are now investigating novel therapeutic interventions for affected patients.

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Appointments & Second Opinions

Speak with one of our New Patient Coordinators to schedule an appointment, refer a patient or request a second opinion. In urgent cases, we can typically see new patients within 24 hours.

Clinical Trials

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Harvard Medical Affiliate

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As a teaching affiliate of Harvard Medical School, our physicians are passing on their expertise to the next generation of pediatric hematologists and oncologists.