• CAR T-Cell Therapy for Pediatric Lymphoma

    Car T-cell therapy - lymphoma banner

    Pediatric B-cell lymphomas, such as Burkitt lymphoma and diffuse large B-cell lymphoma, are usually cured with chemotherapy. However, for patients with lymphoma that does not respond to chemotherapy or that comes back after initial treatment, a cure can be difficult to achieve. CAR (chimeric antigen receptor) T-cell therapy is a promising new treatment for these challenging cases of pediatric non-Hodgkin lymphoma. It works by modifying the patient's own T-cells, a normal part of the body’s immune system, to make cells that hunt and destroy the abnormal cancer cells.

    Learn more about CAR T-cell therapy.

    Who is Eligible for KYMRIAH?

    Dana-Farber/Boston Children’s is a certified treatment center for providing commercially available KYMRIAH, an FDA-approved CAR T-cell therapy, to patients who are 18 years and older with relapsed or refractory large B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL), high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma.

    For more information about whether KYMRIAH is right for your child or to refer a patient, contact:

    Colleen Dansereau, RN
    Director of Clinical Operations, Gene Therapy Program
    Phone: 617-919-7008
    Email: colleen.dansereau@childrens.harvard.edu

    KYMRIAH Clinical Trial

    Dana-Farber/Boston Children’s also has an open clinical trial available to provide KYMRIAH for children and adolescents with relapsed or refractory B-cell lymphomas, including Burkitt lymphoma, diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma (PMBCL), gray zone lymphoma (GZL), and follicular lymphoma (FL). Participants must be under the age of 18.

    Clinical trials are patient studies that test new treatments and therapies. Learn more about participating in clinical trials at Dana-Farber/Boston Children's.

    For more information about whether you or your child is eligible for the clinical trial of KYMRIAH, contact clinicaltrials@danafarberbostonchildrens.org.

    Get answers to frequently asked questions about KYMRIAH and CAR T-cell therapy.

  • Contact Us

    Our specialized new patient coordinators can answer your questions about treatment options and becoming a patient.
  • How Does CAR T-Cell Therapy Work?

  • Find Clinical Trials

    We sponsor and collaborate on clinical trials that break new ground in pediatric cancer and blood disorder treatment. callout bg