Dana-Farber/Boston Children's was the first hospital in New England to offer MIBG therapy (metaiodobenzylguanidine) to treat neuroblastoma (including relapsed or refractory neuroblastoma), and is currently one of only about 10 hospitals in the country to provide this therapy.
Our I-131 MIBG room is a 256-square-foot hospital room designed specifically for this treatment at Boston Children’s Hospital. The room has added protective features to help manage the therapy safely for the benefit of both patients and staff, and has an anteroom where parents can stay to help with the care of their child and be in close proximity throughout the therapy. During the day, parents can spend time with their child following specific safety procedures to protect them, as well as hospital staff.
Metaiodobenzylguanidine (MIBG) is a compound that can be combined with radioactive iodine (I-131) to deliver targeted radiation therapy. I-131 MIBG can be used to treat high-risk neuroblastoma, a cancerous tumor that begins in nerve tissue of infants and very young children. MIBG therapy is generally more effective, less painful, and requires less time in the hospital than other treatment options.
Originally developed as a blood pressure medication, MIBG is a compound that is absorbed by certain types of nerve tissue, including neuroblastoma cells. For many years, it has been used diagnostically to determine where cancerous activity is occurring within the body.
More recently, oncologists began using it to deliver targeted radiation to neuroblastoma. I-131 MIBG is administered to a child through an intravenous line and absorbed by tumor cells, which are killed by radiation emitted by the radioactive I-131. This therapy destroys tumors while sparing normal, healthy tissue. MIBG therapy is currently used to treat relapsed or refractory neuroblastoma and is being studied as a treatment for newly diagnosed high-risk patients.
I-131 MIBG is well tolerated. The major side effect of therapy is low blood counts. A large study showed that 30-40 percent of children with relapsed neuroblastoma respond to MIBG therapy, which makes it one of the most active agents for relapsed disease. While it doesn’t cure neuroblastoma, I-131 MIBG allows patients to gain control of their disease and provide the possibility of prolonged disease stabilization.
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Suzanne Shusterman, MD, describes MIBG therapy, a treatment for neuroblastoma.
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