Delays in diagnosis worsen outlook for minority, uninsured pediatric retinoblastoma patients, study finds
April 27, 2013
When the eye cancer retinoblastoma is diagnosed in racial and ethnic minority children whose families don’t have private health insurance, it often takes a more invasive, potentially life-threatening course than in other children, probably because of delays in diagnosis, Dana-Farber Boston Children's Cancer and Blood Disorders Center researchers will report at this week’s American Society of Pediatric Hematology/Oncology (ASPHO) meeting here.
By analyzing data and tumor samples from 203 children across the United States who had been treated for retinoblastoma, the investigators found that the disease was more invasive at diagnosis in patients who were non-white, Hispanic, uninsured, or covered by Medicaid. Researchers now need to explore why the disease tends to be diagnosed later in such children and how those delays can be eliminated, the study authors say.
Retinoblastomas are tumors that develop during childhood in the light-sensitive retina at the back of the eye. There are about 350 new cases each year in the United States. Treatment may require surgical removal of the affected eye and, if the disease is likely to spread, follow-up chemotherapy.
“The longer that retinoblastomas grow before they’re diagnosed and treated, the more invasive they become and the lower that survival rates are for patients,” says the study’s lead author, Adam Green, MD, of Dana-Farber Boston Children's. “In this study, we used tumor invasiveness as an indicator of delays in disease diagnosis.”
Data and tumor tissue used in the study came from pediatric retinoblastoma patients participating in a clinical trial run by the Children’s Oncology Group, a consortium of more than 8,000 childhood cancer experts on three continents. All the patients had the diseased eye surgically removed, and those whose disease was deemed likely to spread received chemotherapy.
Investigators collected data on patients’ insurance status, race, and ethnicity. The tumor tissue samples were examined by pathologists for signs that the tumors would metastasize.
“We correlated the demographic data with the results of the pathology exams to see if children with retinoblastoma who were non-white, Hispanic, or who did not have private health insurance were more likely to have disease invasiveness at diagnosis requiring chemotherapy in addition to surgery, a stage of disease that may carry a lower survival rate,” Green says. “The answer was yes.”
Of the factors most associated with invasive disease, Hispanic ethnicity had the greatest impact on risk, researchers found, raising the possibility that not speaking English as one’s primary language poses a particular barrier to timely diagnosis and treatment.
“We now need to find out where in the diagnostic process the delays are occurring,” says the senior author of the study, Carlos Rodriguez-Galindo, MD, of Dana-Farber Boston Children's “Is it because patients’ families aren’t familiar with the warning signs of the disease, because they have trouble getting to a primary care doctor or ophthalmologist for an exam, or some other factor? We hope to explore those questions in future studies.”
Co-authors of the study include Bryan Langholz, PhD, of the University of Southern California; Murali Chintagumpala, MD, of Texas Children’s Cancer Center; Patricia Chevez-Barrios, MD, of Methodist Hospital Research Institute; Daniel Albert, MD, MS, of the University of Wisconsin; and Ralph Eagle, MD, of the Wills Eye Institute in Philadelphia.
The research was presented as a platform talk during the 8-9 a.m. session on Saturday, April 27, at the Hyatt Regency Miami.