• A Patient and Doctor Team Come Full Circle

    This article originally appeared on the Boston Children's Thriving blog.

    Kate Franklin as a childKate Franklin was just three and a half years old in August 2000 when her mother, Emily, brought her to the Boston Children’s Hospital emergency room, because she was bruising easily and couldn’t seem to shake a strep throat. Loren Walensky, MD, PhD, had just started his fellowship in pediatric hematology/oncology the month before, and that night, Kate Franklin became one of the first patients he diagnosed with cancer. When Walensky told Emily Franklin that her daughter had leukemia, the mother placed her hands on the doctor’s shoulders, and, in a moment that Walensky says he will never forget, she said, “I will see you at her wedding.”

    Kate Franklin’s wedding day has yet to arrive, but she’s now a 17-year-old rising senior at Bishop Feehan High School in Attleboro who thinks she wants to be a doctor. This summer she’s working in Loren Walensky’s lab, which is exploring the promise of chemically-modified fragments of proteins, called “stapled peptides,” to treat some drug-resistant cancers.

    Kate has been cancer-free since the two years Walensky — now a pediatric oncologist and chemical biologist at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center — spent treating her for acute lymphoblastic leukemia, but they’ve kept in touch.

    When Kate contacted Walensky to see if he knew of any laboratories that would take a high school student for the summer, he invited her to participate in his lab’s internship program for high school and college students considering careers in science and medicine.

    “It’s good to see how a cool opportunity can come out of a hard time,” says Kate. “It makes it come full circle.”

    “It’s the most wonderful thing,” Walensky adds. “Every time I look at her I see that spunky, bright-eyed four-year-old, and here she is all grown up. It’s just profoundly meaningful for her and for me.”

    Kate Franklin and Loren Walensky in the labWalensky has assigned Kate a project adding various synthetically-altered peptides to tissue cultures of stubborn cancers to see which ones help kill malignant cells. She is learning how to handle the peptides, prepare tissue cultures of cancer cells, and examine the cellular responses using a powerful, sophisticated microscope — all work, Walensky notes, that might be done by a graduate student or postdoc.

    “Other than biology class, I haven’t had the opportunity to do science,” Kate says. “This is the real thing.”

    This is exactly why Walensky says he started his Expose-Inspire-Launch internship program in 2006. Current interns include Kate, a 2014 high school graduate about to start college, and a college undergraduate.

    “We’re trying to cultivate the next generation of scientists,” Walensky says. “Having the interns in the lab creates a wonderful dynamic. They remind the older students of those early feelings of ‘wow’ about the wonders of science that inspired them to pursue research careers.”

    Years ago, when Walensky was still a fellow, his patient load grew too rapidly, so a nurse practitioner helped him reassign some patients. Kate Franklin’s name remained on his list. “Kate’s your ray of sunshine,” his colleague told him, “and in this work, you’ll need your ray of sunshine.”

    At Kate’s five-year check-up, the critical moment when the hope of having conquered cancer becomes real, Emily Franklin gave Walensky a special gift: a ceramic wall hanging in the shape of a sun. It now hangs in the family room of his home.

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