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Stuart H. Orkin, MD

Stuart Orkin receives $500,000 Gruber Genetics Prize for his groundbreaking research on the genetics of inherited blood disorders

March 02, 2021
His remarkable body of work has not only revolutionized our understanding of how these illnesses occur but has also led to promising new gene-based therapies for thalassemia and sickle cell disease, two inherited blood disorders that affect millions of people around the world.
vector-sickle-cell

Stuart Orkin and Daniel Bauer receive funding for sickle cell disease research from the Doris Duke Charitable Foundation

September 12, 2019
The Doris Duke Charitable Foundation announced the six projects receiving approximately $5 million through the second Sickle Cell Disease/Advancing Cures grant competition.
Daniel Bauer, MD, PhD - 2

Researchers at Dana-Farber/Boston Children's and UMass Medical School optimize gene editing for sickle cell disease and beta thalassemia

March 28, 2019
Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the University of Massachusetts Medical School have developed a strategy to treat two of the most common inherited blood diseases, sickle cell disease and beta thalassemia, applying CRISPR-Cas9 gene editing to patients' own blood stem cells.
David Williams, MD

Boston Children’s Hospital to receive $1.5M to initiate basic work to expand gene therapy treatment of sickle cell disease into developing countries

December 19, 2018
The research will focus on adapting gene therapy for use in low-resource areas with high rates of the disease.
David Williams, MD

New gene therapy strategy for sickle cell disease shows early promise in humans

December 01, 2018
A patient with a severe form of sickle cell disease is symptom-free after gene therapy knocks down BCL11A and restores fetal hemoglobin production.
vector-sickle-cell

Zeroing in on the fetal-to-adult hemoglobin switch and a new way to combat sickle cell disease

March 29, 2018
In this Vector report, researchers at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center reveal how the protein, BCL11A, controls the switch in the body’s production of fetal hemoglobin to adult hemoglobin.
David Williams, MD

New gene therapy clinical trial offers hope for sickle cell disease

November 14, 2017
David Williams, MD, discusses Dana-Farber/Boston Children's new gene therapy clinical trial for sickle cell disease in a live webchat.
red blood cells

One boy’s cure raises hopes and questions about gene therapy for sickle cell disease

March 01, 2017
Dana-Farber/Boston Children’s researchers, who are developing a gene therapy trial for sickle cell disease, commented in Stat and other outlets on a case report from a different trial.
MatthewMHeeney

Sickle cell disease: An unpredictable adversary

November 19, 2016
One teenage girl describes the intense pain of a sickle cell disease crisis as the feeling that heavy books are piled on her. Her sister likens it to being stabbed by needles. They don’t know when a debilitating crisis will strike, only that it will and that the sudden bouts of pain can last days, The Boston Globe reports.
StuartOrkin_Alt

Gene therapy offers hope for treatment of sickle cell anemia

October 01, 2016
Scientists are finalizing plans to use gene therapy to treat one of the world’s most widespread inherited diseases – sickle cell anemia, the Guardian reports. The technique could begin trials next year, say researchers.
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