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New gene therapy strategy for sickle cell disease shows early promise in humans

December 01, 2018
A patient with a severe form of sickle cell disease is symptom-free after gene therapy knocks down BCL11A and restores fetal hemoglobin production.

Fishing for new leads in rare mucosal melanoma

November 01, 2018
Vector reports that zebrafish are helping scientists dissect intricate molecular pathways in cancer and discover new treatment approaches.

Dana-Farber and Boston Children’s Hospital teams win Moonshot grants

October 05, 2018
The federal Beau Biden Cancer Moonshot program has awarded two grants of $2.5 million over five years to two research teams led by scientists from Dana-Farber/Boston Children’s Cancer and Blood Disorders Center.

In zebrafish, a way to find new cancer therapies, targeting tumor promoters

September 20, 2018
Vector reports on a new study that finds that retinoic acid, best known as an acne treatment, may also be effective in treating adenoid cystic carcinoma.

Leslie Kean, MD, PhD, joins Dana-Farber/Boston Children's Stem Cell Transplantation program

August 08, 2018
Kean will assume overall leadership in the program’s clinical practice and research in coordination with the Clinical Director, Leslie Lehmann, MD.

Dana-Farber/Boston Children's again ranked among the top national pediatric cancer programs

June 26, 2018
U.S. News & World Report has ranked Dana-Farber/Boston Children's Cancer and Blood Disorders Center the top pediatric cancer program in New England and #3 in the nation in its new 2018-19 Best Children's Hospitals report.

Solving the DIPG puzzle a single cell at a time

May 29, 2018
Vector reports that scientists have discovered that DIPG/DMG tumors are made up of H3K27M-mutated cell populations that contain many cells stuck in a stem-cell-like state, fueling tumor growth.

Probing the brain’s earliest development, with a detour into rare childhood cancers

May 22, 2018
In this Vector report, researchers from Boston Children's Hospital found that gaining a greater understanding of how the c-Myc gene functions could lead to new discoveries in neurodevelopment and pediatric cancers.

Pioneering hematologist to receive 2018 Nemmers Prize in Medical Science

May 18, 2018
Stuart H. Orkin, MD, an investigator of the Howard Hughes Medical Institute at Boston Children’s Hospital and Dana-Farber Cancer Institute and professor at Harvard Medical School known for his landmark discoveries into blood cell development and the genetic basis of blood disorders, is the recipient of the 2018 Mechthild Esser Nemmers Prize in Medical Science at Northwestern University.

A bold strategy to enhance CAR T-cell therapies, capable of targeting DIPG and other tough-to-treat cancers

April 27, 2018
As reported in Vector, a Boston-based team of researchers, made up of scientists and pediatric oncologists, believe a better CAR T-cell therapy is on the horizon.
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