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Boston Children’s Hospital to receive $1.5M to initiate basic work to expand gene therapy treatment of sickle cell disease into developing countries

December 19, 2018
The research will focus on adapting gene therapy for use in low-resource areas with high rates of the disease.

CRISPR-Cas9 screen opens new targets for Ewing sarcoma, other childhood cancers

December 18, 2018
In this Vector report, research finds that drugs targeting the TP53 pathway can curb tumor cell proliferation in Ewing sarcoma.

New gene therapy strategy for sickle cell disease shows early promise in humans

December 01, 2018
A patient with a severe form of sickle cell disease is symptom-free after gene therapy knocks down BCL11A and restores fetal hemoglobin production.

Fishing for new leads in rare mucosal melanoma

November 01, 2018
Vector reports that zebrafish are helping scientists dissect intricate molecular pathways in cancer and discover new treatment approaches.

Dana-Farber and Boston Children’s Hospital teams win Moonshot grants

October 05, 2018
The federal Beau Biden Cancer Moonshot program has awarded two grants of $2.5 million over five years to two research teams led by scientists from Dana-Farber/Boston Children’s Cancer and Blood Disorders Center.

In zebrafish, a way to find new cancer therapies, targeting tumor promoters

September 20, 2018
Vector reports on a new study that finds that retinoic acid, best known as an acne treatment, may also be effective in treating adenoid cystic carcinoma.

Leslie Kean, MD, PhD, joins Dana-Farber/Boston Children's Stem Cell Transplantation program

August 08, 2018
Kean will assume overall leadership in the program’s clinical practice and research in coordination with the Clinical Director, Leslie Lehmann, MD.

Dana-Farber/Boston Children's again ranked among the top national pediatric cancer programs

June 26, 2018
U.S. News & World Report has ranked Dana-Farber/Boston Children's Cancer and Blood Disorders Center the top pediatric cancer program in New England and #3 in the nation in its new 2018-19 Best Children's Hospitals report.

Solving the DIPG puzzle a single cell at a time

May 29, 2018
Vector reports that scientists have discovered that DIPG/DMG tumors are made up of H3K27M-mutated cell populations that contain many cells stuck in a stem-cell-like state, fueling tumor growth.

Probing the brain’s earliest development, with a detour into rare childhood cancers

May 22, 2018
In this Vector report, researchers from Boston Children's Hospital found that gaining a greater understanding of how the c-Myc gene functions could lead to new discoveries in neurodevelopment and pediatric cancers.
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