Geoffrey Smith, MD, PhD
Residency: Boston Combined Residency Program
Research interests: Pediatric solid tumors, chemical biology, immuno-oncology, and tumor microenvironment
Geoff received his undergraduate degree in chemistry from Harvard University before working in industry prior to graduate school. He then completed his MD and PhD in chemical biology at the University of California, San Francisco, studying cytokine signaling with Jack Taunton and Art Weiss. In his PhD work, he identified a new JAK3 kinase inhibitor and used it to characterize the consequence of JAK3 inhibition in IL-2 signaling. He collaborated to apply the inhibitor to several therapeutic areas, including graft-versus-host disease (GVHD) and ETP-ALL. He also uncovered differences in CD4 and CD8 T cell IL-2 signaling dynamics that contribute to their distinct proliferative responses. His research has led to multiple publications, including articles in Science Signaling, Nature Chemical Biology, and eLife. In medical school, he developed a love for pediatric oncology while doing a longitudinal oncology clinic and oncology sub internships at UC San Francisco and Boston Children's Hospital. He completed his residency training in the Boston Combined Residency Program (BCRP) in the Accelerated Research Pathway. While in the BCRP, he was a co-leader of the Academy of Basic and Translational Investigation, the BCRP’s community of physician scientists.